A woman in a blue winter jacket and fur-lined hat holds a mug while smiling and looking to the side, enjoying the stunning views during her Patagonia cruise from Santiago to Buenos Aires, with mountains rising across the water.

Santiago to Buenos Aires Mare Australis Patagonia Cruise

*Example by 4 travelers in 4★ accommodation, low season. Flights priced separately. Get a quote for 1 to 99+ below

Summary - Santiago to Buenos Aires Mare Australis Patagonia Cruise

Santiago Buenos Aires Cruise | 4⭐& 5⭐Mare Australis Patagonia

This tour takes you to the two southernmost counties in the continent: Chile and Argentina. Visit Santiago and Buenos Aires their bustling capitals, and discover their history and culture. Not only do these countries share a remarkable ability and natural conditions to produce exquisite wines, but also a place whose surreal sceneries have never ceased to leave visitors speechless: Patagonia.

Start in Santiago de Chile and transfer to Punta Arenas, 100 km (62 mi) from Torres del Paine National Park, and board a Cruise to appreciate the Patagonian fjords and glaciers until arriving at Ushuaia, Argentina, and finish in Buenos Aires.

Please note: The cruise has fixed departures, and therefore this tour needs to start 5 days before the cruise’s departure dates.

Highlights

  • Quito
  • Peguche village
  • Cotacachi market
  • Chaski Antawa train
  • Otavalo indigenous market
  • Avenue of Volcanoes
  • Cotopaxi National Park
  • Baños
  • Riobamba
  • Devil Nose train
  • Inca Cañari Ingapirca ruins

Included

  • 7-Night accommodations
  • All tours, transfers, and entrance fees
  • All breakfasts
  • English-speaking guides

Sample Itinerary

Modern cityscape with tall buildings in the foreground and towering snow-capped mountains in the background under a clear blue sky, evoking the charm of Buenos Aires or a view you might enjoy on a Santiago Wine Tour.
Day 1

Welcome to Santiago, the gateway to the Andes. The colorful capital of Chile sits between majestic mountain peaks and the blue Pacific Ocean. Your SouthAmerica.travel tour guide will accompany you to your hotel in the heart of the city after you arrive. In the afternoon, take a tour to get acquainted with both the historic and modern centers of Santiago and discover the neighboring San Cristobal for a deeper understanding of the area.

A hillside neighborhood with colorful houses and a large church with a tall steeple under a clear blue sky, overlooking the ocean in Valparaíso, Chile—a scenic stop on the journey from Santiago to Buenos Aires or before a Patagonia cruise.
Day 2

Enjoy a full-day excursion to the charming towns of Valparaíso and Viña del Mar. Valparaíso was once the largest port in Chile, a harbor for all shipping vessels in the region. Today, it holds an important place in the political life of the area as the site of the Chilean House of Assembly and Senate and continues to be a major drawcard due to its beauty and cultural heritage. The city is serviced by a network of sixteen funicular railways constructed in the late 1900s primarily to connect the upper and lower parts of the city during a time of rapid economic growth. After stopping in Valparaíso, continue along the coast to the beautiful beaches of Viña del Mar. The latter is affectionately known as the Garden City for its green parks and open spaces where locals and visitors alike can find a natural haven of peace.

Three abandoned boats rest on grassy land near a windy shoreline in Chilean Patagonia, under a bright blue sky with waves on the water and distant hills in the background.
Day 3

Fly south from Santiago direct to Punta Arenas, greet your guide and contemplate the remote and untamed Patagonian landscape on the 4 hour journey to Puerto Natales. Transfer to your hotel upon arrival.

Snow-capped mountains rise behind turquoise lakes and rolling hills under a partly cloudy blue sky, creating a dramatic, sunlit Patagonian landscape—perfect for exploring on a Mare Australis Patagonia Cruise from Santiago to Buenos Aires.
Day 4

A natural sanctuary, the world-famous Torres del Paine National Park is waiting to be explored today. Discover snow-capped mountains, crystal-clear lakes, small waterfalls and endemic flora and fauna. Hike through the varying landscapes and learn about the natural and cultural heritage of this unique region of Patagonia from your expert guide. En route, venture into the Milodon Cave, one of Chile's national monuments which consists of a series of caves. One cave holds the remains of a pre-historic sloth called a milodón. Return to Puerto Natales in the late afternoon.

A small red and white boat sails on a blue lake in Torres del Paine, with snow-capped mountains and a glacier in the background under a clear blue sky.
Day 5

Embark on a sailing trip to see the incredible Balmaceda and Serrano Glaciers. Meet your guide and transfer to Balmaceda Lake. Board the boat, look for playful sea lion colonies along the coastline and pass by Guanaco Island where llamas, alpacas and vicuñas reside, native to the Patagonian region. Try to comprehend the grandeur of the Last Hope Sound, one of the most pristine and spectacular landscapes in Chile’s Patagonia region. Make your way to the Bernardo O'Higgins National Park and be awestruck by the captivating Balmaceda Glacier. Chunks of ice occasionally calve away from this enormous glacier and sink into the waters, a fantastic sight to witness. Sail to the northern side of Balmaceda Mount and absorb the view of the stunning and untouched Serrano Glacier. Disembark from the boat, hike through the native forest and arrive at a small lagoon to take a brief rest and bask in the surrounding environment. Walk to the foot of the Serrano Glacier and sit down to enjoy your lunch before transferring back to your hotel in Puerto Natales.

A person in a blue jacket and fur-lined hat smiles while holding a mug, standing by a railing with a lake and snow-capped mountains in the background—perhaps enjoying the crisp air before embarking on a memorable Patagonia Cruise.
Day 6

Board the Mare Australis vessel and set sail for the nether regions of the southern hemisphere. Sip a welcome cocktail and be greeted by the captain and crew after stepping on deck in the late afternoon. Feel intrepid while cruising through the Strait of Magellan and Beagle Channel, following in the footsteps of pioneers. Explore the breathtaking wilderness of southern Patagonia and Tierra del Fuego and reflect on the harsh but unique beauty of this isolated region of the world.

A group of people stands on a rocky plain with snow-capped mountains and glaciers in the background under a clear blue sky, capturing the wild beauty often seen on a Patagonia cruise from Santiago to Buenos Aires.
Day 7

At dawn, journey through the stunning Almirantazgo Sound and land at Ainsworth Bay in the Alberto De Agostini National Park. Glimpse the translucent and awe-inspiring Marinelli Glacier protruding from the Darwin Mountain Range and learn about the slow but powerful movement of glaciers and how nature comes to life after the retreat of the ice. Discover a beaver dam in the subpolar Magellan forest and keep an eye out for the rare elephant seals. Next, sail to Tuckers Islets, and after lunch set off in the Zodiac boats to observe the fascinating Magellanic Penguins and soaring cormorants in their natural habitat, both endemic to the Southern Hemisphere.

In September and April, this excursion is replaced by a trip to Brookes Bay. Visitors can tentatively step out onto a glacier and experience the wild beauty and adventure of another hidden treasure in this region.

 

A close-up view of a massive blue glacier with jagged ice formations and cracks, rising above dark cold water dotted with floating ice—a striking scene often witnessed on a Patagonia cruise from Santiago to Buenos Aires.
Day 8

Journey through the center of the Beagle Channel to reach the unfathomably deep Pia Fjord. Disembark, take a short hike to a lookout and be rewarded with the unique sight of Pia Glacier extending from the mountain source all the way to the sea. Continue sailing along the northwest section of the Beagle Channel through the intimidating Glacier Alley and be captivated by frozen rivers of ice along the way.

A person in an orange jacket stands near a large, abstract metal sculpture on a dark stone base, set on a grassy area overlooking the ocean—a scene reminiscent of stops along a Patagonia cruise from Santiago to Buenos Aires aboard Mare Australis.
Day 9

Journey to the end of the earth today. Sail through the Beagle and Murray Channels to the Cape Horn National Park and weather permitting, visit Cape Horn, a sheer, rocky 425m-high promontory. Remote, wild and rarely visited, it’s also the final frontier before reaching Antarctica and was declared a World Biosphere Reserve by UNESCO in 2005.

Step ashore at the historic Wulaia Bay. Formerly the site of one of the region's largest Yamana aboriginal settlements, Charles Darwin also landed here in 1833 during the voyage of the HMS Beagle. Be privy to the fierce and arresting natural beauty of the area, the delicate yet resilient vegetation a creation of its unique geographic location and conditions. Walk through a Magellan forest of ferns and other native trees and plants before reaching a lookout to appreciate the landscape.

 

A coastal town with colorful buildings sits by the water in Ushuaia, with snow-capped mountains in the background and several boats, including the Plancius Antarctica cruise ship, docked along the shore under a partly cloudy sky.
Day 10

Arrive in Ushuaia today, the city that sits at the end of the southern hemisphere and the capital city of the Tierra del Fuego. Begin to leave the colder realms of southern Chile behind. Awake early to visit the city’s highlights and its national parks, and finally catch a flight to Buenos Aires.

Two people wearing hats and traditional clothing ride horses side by side, seen from behind, with green trees in the background—evoking the spirit of a Buenos Aires countryside adventure.
Day 11

Experience a slice of rural life with an optional visit to an authentic ranch or estancia. Taste some famous Argentine-style barbecued beef or enjoy a cup of mate accompanied by some pastelitos, a typical local tea and sweet pastries. Go horseback riding or sit back and enjoy a carriage ride and finish the day with an entertaining traditional Gaucho show.

A couple dances tango in front of colorful buildings under a clear blue sky in Buenos Aires. The woman wears a red dress with a red flower in her hair, and the man wears a dark suit.
Day 12

Encounter Buenos Aires, a city bursting with life and often called the “Paris of South America” due to its French-style architecture and culture. Wander along the widest avenue in the world, 9 de Julio Avenue, and see the distinctive Obelisk monument at its head. Visit the classic Colon Theater and French Embassy, the historic Plaza de Mayo and the regal Casa Rosada Presidential Palace. Next, visit the elegant Plaza San Martin and the busy financial district. Capture the essence of tango culture with a walk through the traditional neighborhoods of La Boca, San Telmo and Montserrat. On Sundays, spend a few hours here to browse the antique markets for a few gems from the past. Then wander through the trendy barrio of Palermo, discover the refined elegance of the Recoleta district and end the tour at the renovated Puerto Madero. Formerly Buenos Aires' old port, it now boasts modern skyscrapers, a yacht club, several first-class restaurants and the architectural wonder of the Woman’s Bridge.

Afterward, transfer to the International Airport to catch a flight back home or continue your South America vacation.

 

Santiago to Buenos Aires Mare Australis Patagonia Cruise
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Estimated Tour Price Without Flights

Prices vary according to several factors including: season, number of people traveling, shared vs private excursions, when you book and rooming arrangements. These are from prices based on low season.

We can customize anything for any time of year! Contact us for an exact quote for your trip.

⭐⭐ - ⭐⭐⭐
Budget
From US
$6317
Per Person
⭐⭐⭐⭐
Basic
From US
$7721
Per Person
⭐⭐⭐⭐➕
Superior 👍
From US
$7849
Per Person
⭐⭐⭐⭐⭐
Deluxe
From US
$12125
Per Person

*Budget generally includes excursions in group, Superior & Deluxe private excursions, & Basic is a best mix (varies by itinerary & excurion)

Note: ALL itineraries are 100% customizable to create your perfect trip!

⭐⭐ - ⭐⭐⭐
Budget
From US
$5909
Per Person
⭐⭐⭐⭐
Basic
From US
$7076
Per Person
⭐⭐⭐⭐➕
Superior 👍
From US
$7271
Per Person
⭐⭐⭐⭐⭐
Deluxe
From US
$11239
Per Person

*Budget generally includes excursions in group, Superior & Deluxe private excursions, & Basic is a best mix (varies by itinerary & excurion)

Note: ALL itineraries are 100% customizable to create your perfect trip!

⭐⭐ - ⭐⭐⭐
Budget
From US
$5676
Per Person
⭐⭐⭐⭐
Basic
From US
$6807
Per Person
⭐⭐⭐⭐➕
Superior 👍
From US
$7020
Per Person
⭐⭐⭐⭐⭐
Deluxe
From US
$10908
Per Person

*Budget generally includes excursions in group, Superior & Deluxe private excursions, & Basic is a best mix (varies by itinerary & excurion)

Note: ALL itineraries are 100% customizable to create your perfect trip!

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