🇺🇸 (888) 900-5060
🇺🇸 (888) 900-5060
A multi-country collage showing Machu Picchu, llamas by the sea, a person near Iguazu Falls, and sections of a South America map with a compass, illustrating diverse landscapes and destinations.
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Multi-Country South America Tours

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20+ Years Designing Multi-Country Tours to South America

Maximize your journey with our curated collection of multi-country South America tours. Our travel experts have hand-crafted 15 unique itineraries that seamlessly connect the continent’s most iconic highlights. Whether you’re looking to pair the archaeological wonders of Peru and Machu Picchu with the rugged wilderness of Patagonia, or explore the vibrant cities across several borders, our multi-destination packages offer the ultimate South America experience.

Our Top Multi-Country Tours

  • Aerial view of a city with a park-lined avenue leading to a domed landmark at sunset, surrounded by densely packed buildings under a colorful sky—a scene reminiscent of the Tucuman-Buenos Aires Railway journey.

    The Rhythm of Buenos Aires & Uruguay

    • 8 Days
    • 7 Nights
    • From US $1984
    A map showing a travel route between Buenos Aires, Argentina, and Uruguay’s Montevideo, with stops at Colonia and El Tigre. Icons mark overnights and excursions, while an inset highlights the vibrant rhythm of this South American region.
    Argentina • Uruguay • South America • Multi-Country • Buenos Aires • Patagonia • Montevideo • Punta del Este
  • A bright yellow colonial church with two towers and a detailed baroque entrance stands in a sunlit plaza in South America, with people walking and pigeons near a central fountain under a blue sky—one of the region’s lesser-known world wonders.

    World Wonders of South America

    • 11 Days
    • 10 Nights
    • From US $3228
    A map of South America highlights a travel route from Lima to Rio de Janeiro, featuring World Wonders like Machu Picchu, with stops in Sacred Valley, Cuzco, and Foz do Iguassu. Icons show overnight stays and excursions along the way.
    Brazil • Bolivia • Peru • South America • Multi-Country • Iguazu Falls • Lima • Cusco • Machu Picchu
  • White, Gaudí-inspired Casapueblo building with curved walls and towers overlooks the blue sea in Punta Ballena, Uruguay—a stunning stop on any coast tour. A tree and stone path are in the foreground under a clear sky.

    Coast to Coast Tour

    • 37 Days
    • 36 Nights
    • From US $18887
    A map of South America showing a Coast to Coast Tour route through Peru, Bolivia, Argentina, and Uruguay. Cities, excursions, overnights, flight and ship paths, and country borders are labeled. An inset map shows the region’s global location.
    Multi-Country • Lima • Cusco • Machu Picchu • Lake Titicaca • La Paz • Salar de Uyuni • Argentina • Bolivia • Peru • Uruguay • South America • Buenos Aires • Iguazu Falls • Salta • Quebrada de Humahuaca
  • A scenic view of a small, sandy island surrounded by blue ocean waters, rocky shores, and lush vegetation under a partly cloudy sunset sky—perfect for a Galapagos cruise. In the distance, a larger landmass is visible.

    Galapagos Cruise and Machu Picchu

    • 12 Days
    • 11 Nights
    • From US $6308
    A travel map showing a route from Quito and Otávalo in Ecuador to the Galapagos Islands for a Galapagos Cruise, continuing to Lima, Cuzco, and Machu Picchu in Peru. Symbols indicate overnights and excursions. Includes inset map of South America.
    Galapagos Islands • Multi-Country • Lima • Machu Picchu • Sacred Valley • Quito
  • A person jogs along sandy beaches at sunset, with colorful skies, gentle waves, and lush mountains in the background near a coastal city.
    Popular

    Beaches, Lakes and Waterfalls in South America

    • 14 Days
    • 13 Nights
    • From US $3875
    Argentina • Brazil • Chile • South America • Multi-Country • Buenos Aires • Bariloche • Iguazu Falls • Patagonia
  • Aerial view of Rio de Janeiro at dusk, with city lights glowing, mountains and Sugarloaf Mountain in the foreground—a stunning highlight of any deluxe tour or South America travel adventure under a dramatic sky.

    South America Deluxe Tour

    • 26 Days
    • 25 Nights
    • From US $7244
    A map of South America highlighting a Deluxe Tour travel route from Lima, Peru, through Cuzco, Iguassu Falls, Rio de Janeiro, Curitiba, and Buenos Aires with icons for flights, overnights, and optional excursions.
    Amazon Rainforest • Rio de Janeiro • Atlantic Rainforest • Salvador da Bahia • Argentina • Brazil • Peru • South America • Multi-Country • Buenos Aires • Iguazu Falls • Lima • Machu Picchu
  • A sunny city square with a tall monument in the center, where locals sometimes dance tango, surrounded by grand historic buildings, including a yellow neoclassical structure and ornate white high-rises under a bright blue sky.

    Tango, Samba & Waterfalls

    • 10 Days
    • 9 Nights
    • From US $3536
    Map showing a travel route from Buenos Aires, Argentina, to Rio de Janeiro, Brazil—passing Iguassu Falls' majestic waterfalls, Curitiba, São Paulo, and more—with icons for overnights, excursions, and optional activities. Inset shows South America.
    Argentina • Brazil • South America • Multi-Country • Buenos Aires • Iguazu Falls • Rio de Janeiro • Salvador
  • A vibrant tree covered in bright purple flowers stands in front of an orange stucco building with wooden doors and windows, casting colorful shade along the facade—a charming scene reminiscent of Buenos Aires.
    Popular

    Southern Highlights: Uruguay, Buenos Aires & Brazil Tour

    • 14 Days
    • 13 Nights
    • From US $3665
    Argentina • Brazil • Uruguay • South America • Multi-Country • Buenos Aires • Iguazu Falls • Rio de Janeiro
  • A small red and white boat sails on a blue lake in Argentine Patagonia, with towering, snow-covered mountains and a glacier in the background under a clear blue sky.

    Chilean & Argentine Patagonia Combo

    • 8 Days
    • 7 Nights
    • From US $2846
    Map of southern South America showing a travel route from Buenos Aires through Argentine Patagonia to Torres del Paine in Chilean Patagonia, passing Perito Moreno Glacier, El Calafate, Balmaceda Glacier, and Puerto Natales. Icons indicate transport modes.
    Argentina • Chile • Multi-Country • Buenos Aires • El Calafate • Patagonia • Torres del Paine
  • A river with rapids flows through rocky terrain and lush greenery in Chile, with a snow-capped volcano amid the Andean Lakes, all under a bright blue sky with scattered clouds.

    Chile, Andean Lakes & Buenos Aires

    • 10 Days
    • 9 Nights
    • From US $2747
    Map of southern South America showing a travel route from Santiago, Chile, through Valparaíso, Puerto Varas, across the Andean Lakes to Bariloche, and ending in Buenos Aires, Argentina, with overnights and excursions marked.
    Valparaiso • Andes Mountains • Chile Lake District • Chile • South America • Multi-Country • Buenos Aires • Bariloche • Patagonia
  • A smiling man and woman stand outdoors in a South American vineyard at sunset, holding glasses of red wine and looking at each other. The woman wears a pink dress, and the man wears a white shirt—perfect for a romantic wine tour.

    The South America Wine Tour

    • 10 Days
    • 9 Nights
    • From US $3018
    Map showing a South America Wine Tour route, with stops and overnight stays in Santiago, Valparaiso, Mendoza, Buenos Aires, Colonia del Sacramento, and Montevideo; features winery icons and an inset map for reference.
    Argentina • Chile • Uruguay • South America • Multi-Country • Buenos Aires • Mendoza • Santiago • Valparaiso
  • Silhouettes of a woman and man facing each other, clinking wine glasses at sunset. The orange and yellow sky creates a romantic atmosphere—perfect for a honeymoon in Mendoza.

    Food & Wine Tour of Argentina & Chile

    • 11 Days
    • 10 Nights
    • From US $8883
    Map showing a travel route from Buenos Aires, Argentina, to Mendoza and Santiago, Chile, with icons marking flights, overnights, excursions; includes an inset of South America highlighting the Argentina Chile culinary tour area.
    Argentina • Brazil • Chile • South America • Multi-Country • Buenos Aires • Mendoza • Santiago • Andes Mountains
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South America travel content reviewed by Juergen Keller, Co-Founder & CEO
A vibrant collage highlighting south america tours: a woman with a llama, Rio de Janeiro’s Christ the Redeemer, a boat on turquoise Patagonian waters, Iguazu Falls, and two smiling people leaning from a green train.
Rated 4.5/5 stars based on 701 customer reviews and custom tour testimonials.
With decades of experience crafting journeys across South America, our team combines local expertise, trusted partnerships, and personalized planning to design unforgettable trips. From your first conversation to your return home, we handle the details so you can travel with confidence.
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