Flyout Menu
🇺🇸 (888) 900-5060
A multi-country collage showing Machu Picchu, llamas by the sea, a person near Iguazu Falls, and sections of a South America map with a compass, illustrating diverse landscapes and destinations.
Experts in Tailor-Made

Multi-Country South America Tours

Explore South America Tours
FREE South America Travel Guide
South America Travel Info
Let's Plan Your South America Trip
Customize!
20+ Years Designing Multi-Country Tours to South America

Maximize your journey with our curated collection of multi-country South America tours. Our travel experts have hand-crafted 15 unique itineraries that seamlessly connect the continent’s most iconic highlights. Whether you’re looking to pair the archaeological wonders of Peru and Machu Picchu with the rugged wilderness of Patagonia, or explore the vibrant cities across several borders, our multi-destination packages offer the ultimate South America experience.

Our Top 15 Multi-Country Tours

  • Aerial view of a city with a park-lined avenue leading to a domed landmark at sunset, surrounded by densely packed buildings under a colorful sky—a scene reminiscent of the Tucuman-Buenos Aires Railway journey.

    The Rhythm of Buenos Aires & Uruguay

    • 8 Days
    • 7 Nights
    • From US $1984
    Tour beautiful Santander Colombia. Visit Barichara colonial village & explore Chicamocha National Park to see amazing mountain landscapes.
  • A bright yellow colonial church with two towers and a detailed baroque entrance stands in a sunlit plaza in South America, with people walking and pigeons near a central fountain under a blue sky—one of the region’s lesser-known world wonders.

    World Wonders of South America

    • 11 Days
    • 10 Nights
    • From US $3228
    See the beer flow at the second biggest Oktoberfest in the world at Blumenau, Brazil. 4* & 5* Oktoberfest tour plus Rio de Janeiro & Sao Paulo
  • White, Gaudí-inspired Casapueblo building with curved walls and towers overlooks the blue sea in Punta Ballena, Uruguay—a stunning stop on any coast tour. A tree and stone path are in the foreground under a clear sky.

    Coast to Coast Tour

    • 37 Days
    • 36 Nights
    • From US $18887
    Argentina & Brazil Golf Tour. Golf on some of the best courses and visit the top destinations in Argentina & Brazil on this one of a kind Golf Tour. Explore all the top destinations including Buenos Aires, Rio de Janeiro, and Salvador da Bahia and play golf with some of the best views with SouthAmerica.travel, Brazil & Argentina tours experts.
  • A scenic view of a small, sandy island surrounded by blue ocean waters, rocky shores, and lush vegetation under a partly cloudy sunset sky—perfect for a Galapagos cruise. In the distance, a larger landmass is visible.

    Galapagos Cruise and Machu Picchu

    • 12 Days
    • 11 Nights
    • From US $6308
    Explore Colombia’s coffee region & taste the world’s best coffee. See the Andes Mountains & volcanoes & stay on a real Colombian coffee farm.
  • A person jogs along sandy beaches at sunset, with colorful skies, gentle waves, and lush mountains in the background near a coastal city.

    Beaches, Lakes and Waterfalls in South America

    • 14 Days
    • 13 Nights
    • From US $3875
    Join our Group Tour of Patagonia! Arrive for an amazing trip through South America’s most scenic corner on a scheduled departure 26 Mar 2026
  • Aerial view of Rio de Janeiro at dusk, with city lights glowing, mountains and Sugarloaf Mountain in the foreground—a stunning highlight of any deluxe tour or South America travel adventure under a dramatic sky.

    South America Deluxe Tour

    • 26 Days
    • 25 Nights
    • From US $7244
    Buenos Aires & Montevideo Tour | Argentina & Uruguay Tours. Customize a Classic 4-star & 5-star Argentina & Uruguay Tour with SouthAmerica.travel, the South America tours & travel experts. Explore Buenos Aires, Argentina all the way to colorful Montevideo, Uruguay in one complete tour package.
  • A sunny city square with a tall monument in the center, where locals sometimes dance tango, surrounded by grand historic buildings, including a yellow neoclassical structure and ornate white high-rises under a bright blue sky.

    Tango, Samba & Waterfalls

    • 10 Days
    • 9 Nights
    • From US $3536
    Visit the archeological treasures of Northern Peru on this 4* & 5* Peru tour to Chan Chan, Trujillo, Chiclayo, Cajamarca and more.
  • A vibrant tree covered in bright purple flowers stands in front of an orange stucco building with wooden doors and windows, casting colorful shade along the facade—a charming scene reminiscent of Buenos Aires.

    Southern Highlights: Uruguay, Buenos Aires & Brazil Tour

    • 14 Days
    • 13 Nights
    • From US $3665
    Patagonia lends itself as the perfect family destination for outdoor enthusiasts to create a special bond with nature’s beauty.
  • A small red and white boat sails on a blue lake in Argentine Patagonia, with towering, snow-covered mountains and a glacier in the background under a clear blue sky.

    Chilean & Argentine Patagonia Combo

    • 8 Days
    • 7 Nights
    • From US $2846
    Explore the exotic Galapagos Islands on one amazing Ecuador Tour! In just 6 days, visit three of the most popular Galapagos Islands. Relax on the beaches of Santa Cruz, learn about the pirates while visiting Floreana & spot wildlife at Isabela Island.
  • A river with rapids flows through rocky terrain and lush greenery in Chile, with a snow-capped volcano amid the Andean Lakes, all under a bright blue sky with scattered clouds.

    Chile, Andean Lakes & Buenos Aires

    • 10 Days
    • 9 Nights
    • From US $2747
    Ride through Argentina & Chile on the railway, and explore Patagonia by rail on this unique South America train tour with SouthAmerica.travel
Load More Tours

Create Your Own Custom Tour

Click or Tap your preferences: Destinations & Activities. Be as specific or general as you like – or click Help Me Decide! We’ll spice it with hidden gems & personal tips to create your perfect trip. Need assistance? Contact an expert at 🇺🇸 (888) 900-5060

Step 1 of 6 - Destinations

Choose Destinations
Destinations
Amazon Interests
Argentina Interests
Bolivia Interests
Brazil Interests
Chile Interests
Colombia & Panama Interests
Ecuador & Galápagos Interests
Paraguay & Uruguay Interests
Patagonia & Antarctica Interests
Peru & Machu Picchu Interests
Guianas Interests
Choose Interests

Why Plan Your Journey with Us

A vibrant collage highlighting south america tours: a woman with a llama, Rio de Janeiro’s Christ the Redeemer, a boat on turquoise Patagonian waters, Iguazu Falls, and two smiling people leaning from a green train.
With decades of experience crafting journeys across South America, our team combines local expertise, trusted partnerships, and personalized planning to design unforgettable trips. From your first conversation to your return home, we handle the details so you can travel with confidence.
South America Travel Guide PDF Cover Page.
Download your free

South America Travel Guide

Download our FREE South America Travel Guide and get inspired to explore to South America. Browse through 26 pages of travel planning tips and ideas – a great resource for planning your dream vacation.
  • Colorful maps and images
  • Unique hotels within South America
  • Inspiration for cruises, remote lodges and trains
  • Wine, golf and adventure ideas
  • 24 top tours of South America
Get My Free Guide

South America Travel Info

Icon
South America Hotels & Resorts
Icon
South America Articles
Icon
South America Staying Healthy
Icon
Internet & Calling in South America
Icon
South America Travel Insurance
Icon
South America Packing List
Icon
Money in South America
Icon
South America Visa Requirements
Icon
South America Flights
Icon
Weather in South America
Icon
Languages of South America
Icon
South America Food & Drink
Icon
Safety in South America
Your Experts in South America!

Let's Design Your Perfect Trip

Four people work at standing desks with headsets and computers in a bright office. A colorful “SouthAmerica.travel” banner and destination photos are displayed in the background.
We Love to Talk About South America Trip Ideas!

Thinking of traveling to South America? We take your South American travel dream and make it a reality. Every fully custom South America trip is planned by your own expert personal Travel Consultant.

"*" indicates required fields

This field is for validation purposes and should be left unchanged.
Full Name

We ❤️ to talk! A brief chat with your personal Travel Consultant helps us create your perfect trip!

Apply